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DTSTAMP:20260906T202827Z
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DTSTART:20261008T100000
DTEND:20261008T113000
DESCRIPTION:Despite the availability of vaccines\, there remains a need for
  safe and effective antiviral drugs against coronaviruses to treat vulnera
 ble patients\, control transmission\, and prepare for future outbreaks. In
  the spring of 2020\, our lab was part of a global race to the 3D structur
 e of the coronavirus SARS-Cov2 RNA-dependent RNA polymerase and provided m
 echanistic insights into viral RNA replication. We later also used structu
 re-function studies to reveal the mechanisms of antiviral drugs such as re
 mdesivir and molnupiravir\, revealing key limitations in their efficacy an
 d safety. Building on this framework\, we are identifying novel polymerase
  inhibitors through large-scale chemical screening\, in the hope to uncove
 r leads for the development of next-generation antiviral therapies.
LOCATION:ETH Zürich\, Hönggerberg HIT E 51
ORGANIZER:Patrick Cramer
SUMMARY:Antivirals against SARS-Cov2 polymerase
URL;VALUE=URI:https://pauli-lectures.ethz.ch/lectures26.html
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